PewterReport.com is reporting Bucs center Jeff Faine (triceps), wide receiver Antonio Bryant (knee), defensive lineman Kyle Moore (groin) and cornerback E.J. Biggers (shoulder) are being held out of Wednesday's practice at One Buc Place.
Faine has already been ruled out of the game in Buffalo. He will be replaced by Sean Mahan. Bryant is considered day-to-day.
Linebacker Adam Hayward (ankle), guard Jeremy Zuttah (ankle) tight end John Gilmore (quad) are participating in practice today.
Pewter Report will have more on this story later today.